Difference Between Lactobacillus And Bacillus Clausii

Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Among the myriad of bacterial species marketed as probiotics, Lactobacillus and Bacillus Clausii are two prominent types that have captured the attention of both the medical community and health-conscious individuals. These bacteria are not only fundamental to gut health but also play a crucial role in overall wellness.

Lactobacillus is a genus of bacteria known for its benefits in the digestive system and for supporting immune function. In contrast, Bacillus Clausii is a spore-forming bacterium adept at surviving harsh stomach environments, making it particularly effective in treating and preventing various gastrointestinal disorders. The primary distinction lies in their survival mechanisms and their interactions with the human body.

Both Lactobacillus and Bacillus Clausii are instrumental in maintaining gastrointestinal health, but they do so in markedly different ways. Lactobacillus primarily enhances the intestinal flora and aids in digestion, while Bacillus Clausii can help combat intestinal microbial imbalances, often prescribed during or following antibiotic therapy. This dynamic duo of probiotics offers extensive health benefits ranging from improving gut health to boosting the immune system.

Probiotic Categories

Probiotics are classified into different categories based on their bacterial species and the unique benefits they provide. Among these, Lactobacillus and Bacillus Clausii are two commonly studied types, each playing a pivotal role in maintaining human health.

Definition of Lactobacillus

Lactobacillus is a type of bacteria that falls under the category of lactic acid bacteria, found predominantly in the digestive system, as well as in the urinary and genital systems. These bacteria are known for their ability to convert lactose and other sugars into lactic acid, which helps inhibit the growth of harmful bacteria and maintain a healthy gut environment.

Definition of Bacillus Clausii

Bacillus Clausii is a spore-forming bacterium that is widely used as a probiotic. Unlike many other probiotic bacteria, Bacillus Clausii can survive harsh gastric environments, thanks to its ability to form protective endospores. This capability allows it to reach the intestine intact, where it can exert its beneficial effects.

ALSO READ:  What Is The Difference Between Effervescence And Efflorescence

Key Features

General Characteristics of Lactobacillus

Lactobacillus species are gram-positive, rod-shaped bacteria that are key players in the food industry, particularly in the production of yogurt, cheese, sauerkraut, pickles, and other fermented foods. In the human body, these bacteria adhere to the mucosa and epithelial cells of the gut, forming a barrier against pathogens and contributing to the immune function:

  • Acid tolerance: Thrives in acidic environments, which is crucial for survival in the stomach.
  • Oxygen sensitivity: Most species are microaerophilic, meaning they require lower levels of oxygen to live.

General Characteristics of Bacillus Clausii

Bacillus Clausii is uniquely capable of forming spores that protect its genetic material in adverse conditions. This ability not only contributes to its robustness but also to its versatility in medical applications. Key features include:

  • Spore formation: Allows survival through the acidic conditions of the stomach.
  • Antibiotic resistance: Can survive antibiotic treatment, making it an excellent adjunct therapy.

Health Benefits

Benefits of Lactobacillus

Lactobacillus bacteria offer numerous health benefits, particularly related to gut health and immune function:

  • Digestive health: Helps break down food, absorb nutrients, and fight off harmful bacteria.
  • Immune support: Enhances the immune system by increasing the number of antibodies and promoting immune cells.
  • Cholesterol reduction: Some strains can help lower cholesterol levels by breaking down bile in the gut.

Benefits of Bacillus Clausii

Bacillus Clausii is often recommended for its ability to restore and maintain the natural balance of intestinal flora, especially during or following antibiotic therapy:

  • Gastrointestinal support: Helps to treat symptoms of diarrhea and other digestive disorders.
  • Flora restoration: Replenishes good bacteria affected by antibiotics.
  • Immune modulation: Supports the immune system by enhancing the body’s natural defenses.

Usage in Medicine

Lactobacillus Applications

Lactobacillus is extensively used in the medical field due to its beneficial effects on human health:

  • Prevention and treatment of diarrhea: Effective in preventing and treating various types of diarrhea, including rotavirus diarrhea in children and traveler’s diarrhea.
  • Allergy alleviation: Some studies suggest that Lactobacillus can reduce the severity of allergies, particularly atopic dermatitis in infants.
  • Mental health implications: Emerging research links gut health with mood and mental health, suggesting Lactobacillus might play a role in improving symptoms of depression and anxiety.

Bacillus Clausii Applications

Due to its resilience and efficacy, Bacillus Clausii is particularly useful in various medical scenarios:

  • Antibiotic-associated treatments: Used to prevent and treat the effects of antibiotic-associated diarrhea and other gastrointestinal complaints.
  • Chronic gastrointestinal diseases: Helps manage symptoms of chronic conditions such as irritable bowel syndrome (IBS).
  • Immune system enhancement: Its ability to modulate the immune response is utilized in boosting the immune system, particularly in immunocompromised individuals.
ALSO READ:  What Is The Difference Between Tretinoin And Retinol

Clinical Studies

Research on Lactobacillus

Extensive research has been conducted on Lactobacillus, highlighting its potential in treating and preventing a variety of health conditions. Clinical studies have shown promising results in areas such as gastrointestinal health, immune system support, and even mental health. For instance, a randomized controlled trial published in the Journal of Pediatric Gastroenterology and Nutrition found that Lactobacillus rhamnosus GG effectively reduced the duration of infectious diarrhea in children. Other studies have explored the role of Lactobacillus in managing symptoms of irritable bowel syndrome (IBS), with some strains helping to alleviate bloating and abdominal pain.

Further, research extends into the realm of mental health, where probiotics like Lactobacillus are considered potential adjunct therapies for depression and anxiety. This is based on the gut-brain axis, a pathway through which the gut flora can influence brain health. A study in the American Journal of Clinical Nutrition noted improvements in mood and psychological distress among participants taking Lactobacillus supplements.

Research on Bacillus Clausii

Bacillus Clausii has been the subject of various clinical trials, particularly in its effectiveness against gastrointestinal disorders and its role in maintaining intestinal flora during antibiotic treatments. Research published in the International Journal of Antimicrobial Agents demonstrates that Bacillus Clausii can help in the prevention of antibiotic-associated diarrhea, a common side effect of antibiotic use. Its spore-forming nature allows it to pass through the stomach’s acidic environment intact, reaching the intestines where it can exert its beneficial effects.

Studies also suggest that Bacillus Clausii may support immune health. In a clinical setting, it has been shown to enhance the immune response in children, reducing the incidence of respiratory tract infections.

Safety and Side Effects

Lactobacillus Considerations

While Lactobacillus is generally safe for most people, there are specific considerations to keep in mind:

  • Allergy and Intolerance: Rarely, individuals may experience allergic reactions or lactose intolerance symptoms.
  • Immune System Impact: People with weakened immune systems should consult healthcare providers before starting any probiotic regimen, as there is a slight risk of infection.
  • Long-term Use: The long-term effects of extensive Lactobacillus supplementation are still under investigation, and it is wise to follow medical advice for prolonged use.

Bacillus Clausii Considerations

Bacillus Clausii is also considered safe, but similar precautions apply:

  • Spore Activation: While the spore-forming ability of Bacillus Clausii is beneficial for survival through the stomach, it means it can also colonize more robustly, which might be problematic in very immunocompromised individuals.
  • Antibiotic Resistance: As Bacillus Clausii can survive antibiotic treatment, it is crucial to ensure it does not contribute to antibiotic resistance patterns in the microbiota.
ALSO READ:  What Is The Difference Between Formal And Informal Communication

Choosing Probiotics

Factors to Consider

Selecting the right probiotic involves considering several factors to ensure effectiveness and safety:

  • Strain Specificity: Different strains of the same species may have different effects. It’s important to choose a strain that has been clinically validated for the specific health condition being targeted.
  • CFU Count: The colony-forming units (CFU) indicate the amount of live microbes in a probiotic. Higher CFU counts are typically more effective, but the optimal count can vary based on the condition.
  • Quality and Purity: High-quality, pure probiotic formulations reduce the risk of contaminants and ensure the product contains live, active cultures.


When choosing a probiotic:

  1. Consult a Healthcare Provider: Especially if you have underlying health conditions or are on medication.
  2. Check for Clinical Evidence: Opt for products that have been supported by clinical trials.
  3. Consider Your Needs: Whether it’s for general health, specific gastrointestinal issues, or immune support, the choice of probiotic should match your health goals.

Frequently Asked Questions

What is Lactobacillus?

Lactobacillus is a genus of bacteria naturally found in the digestive, urinary, and genital systems. These bacteria convert lactose and other sugars into lactic acid, which helps control harmful bacteria growth and plays a key role in overall gut health.

What is Bacillus Clausii?

Bacillus Clausii is a spore-forming probiotic that is known for its ability to survive in harsh environments, such as gastric acids. It is often used to restore the natural flora in the human intestine, especially during or after antibiotic treatments.

How do Lactobacillus and Bacillus Clausii differ?

While both are probiotics, Lactobacillus functions primarily in the gut by breaking down sugars into lactic acid, supporting digestion and inhibiting harmful bacteria. Bacillus Clausii, on the other hand, forms spores that can endure stomach acid, making it particularly effective in treating and preventing gastrointestinal disturbances.

Can Lactobacillus and Bacillus Clausii be taken together?

Yes, Lactobacillus and Bacillus Clausii can be taken together. Combining these probiotics can potentially offer synergistic benefits, enhancing gut health and immunity by maintaining a balanced intestinal flora.


In conclusion, Lactobacillus and Bacillus Clausii both play significant roles in promoting gut health and beyond, but they do so through different mechanisms. While Lactobacillus improves digestive health by aiding in the breakdown of sugars and enhancing the gut flora, Bacillus Clausii offers unique advantages in gastrointestinal resilience and the ability to thrive during antibiotic use.

Understanding the distinct qualities of these probiotics helps in making informed decisions about their use in maintaining health and combating digestive issues. Whether choosing one over the other or using them in tandem, Lactobacillus and Bacillus Clausii stand as powerful allies in the quest for optimal health.

Leave a Comment